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探讨成人急性淋巴细胞白血病免疫表型与预后的关系。采用形态学、免疫学检测方法,对46例急性淋巴细胞白血病免疫表型进行回顾性分析总结。结果:①在T-ALL中,CD7、CD2表达率较高,B-ALL中CD19、CD10、CD20表达率较高,部分ALL中有髓系相关抗原CD33、CD13及祖/干细胞免疫表型CD34、HLA-DR表达,且其阳性表达率与ALL的预后相关;②46例ALL经诱导治疗后,38例CR,总CR率82.6%;CD13+ALL(51.8%)与CD13-ALL(66.7%)、CD34+ALL(51.1%)与CD34-ALL(61.4%)患者CR率相比无统计学意义(P>0.05),HLA-DR+ALL(48.6%)低于HLA-DR-ALL(75%),两者之间差别有统计学意义(P<0.05)。免疫分型为白血病的诊断、治疗及预后判断有重要的临床意义。
To investigate the relationship between immunophenotype and prognosis of adult acute lymphoblastic leukemia. The morphological and immunological methods were used to analyze the immunophenotype of 46 cases of acute lymphoblastic leukemia. Results: ①The expression of CD7 and CD2 was higher in T-ALL, and the expression rates of CD19, CD10 and CD20 were higher in B-ALL. The immunophenotypic CD33, CD13 and pro-stem / , HLA-DR expression, and the positive expression rate was correlated with the prognosis of ALL. (2) The CR rate of 38 CR patients was 82.6% in all the 46 ALL patients. The CD13 + ALL (51.8%) and CD13- There was no significant difference in the CR rate between CD34 + ALL (51.1%) and CD34-ALL (61.4%) (P> 0.05) ), The difference between the two was statistically significant (P <0.05). Immunophenotyping for the diagnosis, treatment and prognosis of leukemia have important clinical significance.