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Objective: To compare danazol and gestrinone treatment as preoperative endometrial preparation for operative hysteroscopy. Design: Prospective, randomized clinical study. Setting: University department of gynecological, obstetrical sciences and reproductive medicine. Patient(s): One hundred thirty-five patients with endouterine pathologies (endometrial polyps, submucous myoma, septate uterus). Intervention(s): Patients pretreated with gestrinone (n = 68) and with danazol (n = 67)- underwent operative hysteroscopy. Main Outcome Measure(s): Endometrial response to the medical pretreatment, side effects, procedure time, intraoperative bleeding, infusion volume, patient satisfaction. Result(s): Side effects were infrequent in both groups, though the patients’ personal satisfaction was in favor of gestrinone. The rate of endometrial response was higher for the gestrinone group (97.1% vs. 83.6% ). Operative time (mean ± SD) was 12 ± 1.8 and 15.2 ± 1.9 minutes for the gestrinone and danazol groups, respectively. The gestrinone group showed a lower incidence of moderate bleeding (3% vs. 22.4% ) and a lower infusion volume (2,100 ± 200 mL vs. 2,400 ± 250 mL). Regarding cervical dilatation time, no significant difference was found between the two groups (1.6 ± 0.3 minutes vs. 1.5 ± 0.4 minutes). Conclusion(s): Both treatments are good ways to prepare the endometrium for operative hysteroscopy. However, the data suggest that gestrinone pretreatment is preferable to danazol.
Objective: To compare danazol and gestrinone treatment as preoperative endometrial preparation for operative hysteroscopy. Design: Prospective, randomized clinical study. Setting: University department of gynecological, obstetrical sciences and reproductive medicine. Patient (s): One Hundred thirty-five patients with endouterine Pathologies (endometrial polyps, submucous myoma, septate uterus). Intervention (s): Patients pretreated with gestrinone (n = 68) and with danazol (n = 67) - underwent operative hysteroscopy. Results (s): Side effects were infrequent in both groups, though the patients’ personal satisfaction was in favor of gestrinone. The rate of endometrial response was higher for the gestrinone group (97.1% vs. 83.6%). Operative time (mean ± SD) was 12 ± 1.8 and 15.2 ± 1.9 minutes for the gestrinone and danazo Regarding cervical dilatation time, no significant difference was found between the groups with a lower incidence of moderate bleeding (3% vs. 22.4%) and a lower infusion volume (2,100 ± 200 mL vs. 2,400 ± 250 mL) Conclusion (s): Both treatments are good ways to prepare the endometrium for operative hysteroscopy. However, the data suggest that gestrinone pretreatment is preferable to danazol.