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恶性血液病患者因接受大剂量化疗,应用免疫抑制剂及广谱强效抗生素,造成中性粒细胞严重减少,免疫功能明显下降,极易发生侵袭性真菌感染(IFI)。抗真菌治疗疗程长,而多数并发真菌感染者的基础疾病重,对药物耐受性差,老年患者更为突出。我院采用卡泊芬净治疗恶性血液病并发IFI患者41例,观察其疗效和安全性,报告如下。
Due to high-dose chemotherapy, immunosuppressive agents and a broad spectrum of potent antibiotics cause hematopoietic malignancies to cause a severe decrease in neutrophils, a marked decrease in immune function and a high susceptibility to invasive fungal infection (IFI). Anti-fungal treatment of long courses, while the majority of patients with concurrent fungal infections of the basic diseases, poor tolerance to drugs, elderly patients are more prominent. In our hospital, caspofungin treatment of 41 cases of hematologic malignancy complicated with IFI, to observe its efficacy and safety, the report is as follows.