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目的 :探讨氧化修饰低密度脂蛋白 (ox LDL)引发的免疫反应在动脉粥样硬化 (AS)发生发展中的作用 ,揭示ox LDL致AS的免疫学机制。方法 :90例冠心病 (CHD)患者 (分为 3组 :稳定型心绞痛组、不稳定型心绞痛组、急性心肌梗死组 ) ,采用ELISA法检测其血液中ox LDL、ox LDL Ab及ox LDL IC水平。并入选 4 0例健康人群作为对照组。结果 :CHD各组血液中ox LDL、ox LDL Ab及ox LDL IC水平明显高于对照组 ,以急性心肌梗死组为最高。 3项指标的阳性率以ox LDL IC为最高。ox LDL Ab与血清脂蛋白无关 ,与ox LDL呈负相关 ,与ox LDL IC正相关。结论 :ox LDL的免疫反应参与AS的发生发展 ,这是细胞和分子的一系列复杂的免疫炎症反应过程
Objective: To investigate the role of ox LDL-induced immune response in the development of atherosclerosis (AS) and to reveal the immunological mechanism of ox LDL-induced AS. Methods: Ninety patients with coronary heart disease (CHD) were divided into three groups: stable angina pectoris group, unstable angina pectoris group and acute myocardial infarction group. The blood levels of ox LDL, ox LDL Ab and ox LDL IC Level. 40 healthy people were selected as the control group. Results: The blood levels of ox LDL, ox LDL Ab and ox LDL IC in CHD group were significantly higher than those in control group, and were the highest in acute myocardial infarction group. The positive rate of three indicators to ox LDL IC highest. Ox LDL Ab was independent of serum lipoprotein, negatively correlated with ox LDL, and positively correlated with ox LDL IC. CONCLUSION: The immune response of ox LDL is involved in the development of AS, which is a series of complex immune and inflammatory reaction processes of cells and molecules