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目的通过观察更年期心律失常女性血浆中心钠素(ANP,中文摘要中无须给出英文全名,这不是中文摘要的任务)水平的改变,探讨心律失常的发生与心钠素的关系。方法58例更年期女性分为心律失常组31例和正常对照27例,治疗前及治疗8周后分别用放免法测定血浆心钠素浓度,同时测定心率。结果正常对照组27例血浆ANP基础水平为(15±8)ng/L,心律失常组31例患者为(30±12)ng/L,二者比较具有显著差异(P<0.01),心律失常组抗心律失常治疗有效23例,治疗血浆ANP水平为(17±10)ng/L,与治疗前相比明显降低(P<0.05),血浆ANP水平与心率呈正相关性(r=0.76,P<0.05)。结论更年期女性心律失常患者血浆中ANP水平明显高于正常人群。
Objective To investigate the relationship between the occurrence of arrhythmia and atrial natriuretic peptide (ANP) by observing the changes of plasma atrial natriuretic peptide (ANP) in menopausal women with arrhythmia and without changing the English name of the Chinese abstract. Methods 58 cases of menopausal women were divided into the arrhythmia group of 31 cases and 27 cases of normal control before treatment and 8 weeks after treatment, respectively, by radioimmunoassay plasma atrial natriuretic peptide concentration, heart rate. Results The plasma level of ANP was (15 ± 8) ng / L in 27 cases of normal control group and (31 ± 12) ng / L in 31 cases of arrhythmia group, with significant difference (P <0.01) The anti-arrhythmic effect was observed in 23 cases. The level of plasma ANP was (17 ± 10) ng / L, significantly lower than that before treatment (P <0.05). The plasma ANP level was positively correlated with heart rate (r = 0.76, P <0.05). Conclusions Plasma ANP levels in menopausal women with arrhythmia were significantly higher than those in normal subjects.