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利用脂酶催化拆分公胺基醇的方法，可以对外消旋的倍他洛尔或其中间体1-氯-3－［4-（2-环丙基甲氧基）乙基〕苯氧基丙-2-醉（1）进行拆分。前法是在合成外消旋倍他洛尔后，将它和乙酸盯在吡啶中进行N，O-双乙酸化，再在酶催化条件下选择性水解，实验证明只有PPL和K－10这两种酶
The racemate of betaxolol or its intermediate 1-chloro-3- [4- (2-cyclopropylmethoxy) ethyl] phenoxy Keprenyl-2 drunk (1) for resolution. The former method is that after racemic betaxol is synthesized, it is stained with acetic acid in pyridine for N, O-diacetylation and then selectively hydrolyzed under enzymatic catalysis. Experiments show that only PPL and K-10 are the two Enzymes