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分析361例长期服0.1～0.4g/日胺碘酮的不良反应及其血药浓度变化。不良反应发生率为24%。98例中71%有效者血药浓度为0.5～1.5μg/ml。服固定维持量后1个月起血药浓度即可达相对稳态。本文并对血药浓度变化的临床意义进行了讨论。
Analysis of 361 long-term service 0.1 ~ 0.4g / day amiodarone adverse reactions and changes in plasma concentrations. The incidence of adverse reactions was 24%. The effective concentration of plasma in 71% of 98 cases was 0.5 ~ 1.5μg / ml. Serve a fixed amount of blood plasma concentration up to 1 month after the relative steady state. This article also discussed the clinical significance of blood concentration changes.