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心力衰竭(HF)的重要病理生理改变是心脏泵功能受损、外周循环阻力增高和钠水潴留。后两种改变的代偿意义是保证重要脏器的血供和增加心室充盈以维持心输出量,但同时又使病变心脏处于不利的工作负荷状态,心肌耗氧量增加,心泵功能进行性恶化,形成了HF发生和发展的恶性循环。现已确认,神经内分泌机制异常在其中起了重要的中介作用(图1)。近年来这方面的研究成果丰富了HF病理生理学的内容,促进了HF临床治疗学的发展。本文综述近年来这一领域中的研究进展。
Important pathophysiological changes in heart failure (HF) are impaired cardiac pump function, increased peripheral circulation resistance, and sodium and water retention. The latter two kinds of changes compensatory significance is to ensure the blood supply of important organs and to increase ventricular filling to maintain cardiac output, but at the same time make the diseased heart in an unfavorable working condition, increased myocardial oxygen consumption, cardiac pump progressive Worsen, forming a vicious circle of occurrence and development of HF. It has been confirmed that abnormal neuroendocrine mechanisms play an important intermediary role (Figure 1). In recent years, research results in this area enriched the content of HF pathophysiology and promoted the development of HF clinical therapeutics. This article summarizes the research progress in this area in recent years.