论文部分内容阅读
目的分析儿童乙型肝炎病毒(HBV)感染的危险因素,为降低其感染率提供依据。方法采取多阶段随机抽样方法抽取1～20岁常住儿童及青少年,对其乙肝疫苗接种情况及主要乙肝感染危险因素等进行问卷调查,并采集静脉血检测乙肝血清学指标,按是否感染HBV分为病例组和对照组,进行单因素分析并拟合多因素Logistic回归模型。结果 366名调查对象中感染HBV70例,感染率为19.12%;经单因素和多因素分析,密接者HBsAg状况、乙肝疫苗接种史、出生地点是影响儿童感染HBV的危险因素。结论当前降低HBV感染率的工作重点在于发现HBsAg阳性孕妇并建议其到较好的医院分娩,同时改善卫生状况较差的地区特别是农村儿童乙肝疫苗接种状况。
Objective To analyze the risk factors of hepatitis B virus (HBV) infection in children and provide basis for reducing their infection rate. Methods A multi-stage random sampling method was adopted to collect children and adolescents aged from 1 to 20 years. The hepatitis B vaccination status and risk factors of major hepatitis B infection were investigated by questionnaire. Venous blood samples were collected for the detection of hepatitis B serological markers. Case group and control group, univariate analysis and fitting multivariate Logistic regression model. Results Among 366 subjects, 70 cases were infected with HBV, the infection rate was 19.12%. Univariate and multivariate analysis showed that the HBsAg status, hepatitis B vaccination history and place of birth were the risk factors of HBV infection in children. Conclusions The current focus of efforts to reduce HBV infection is to identify HBsAg-positive pregnant women and advise them to have better hospital deliveries and to improve hepatitis B vaccination in poorly-sanitized areas, especially rural children.