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目的:观察脑出血、脑梗死、蛛网膜下腔出血患者血浆神经降压素(neurotensin,NT)水平改变及其动态变化,探讨NT参与各型脑卒中及其伴发病中的病理生理机制及对功能预后评估的意义。方法:2002-03/2003-09,实验在济南长城医院神经内科、山东大学附属第二医院神经内科、山东省立医院、山东大学齐鲁医院神经内科与泰山医学院微循环研究所完成。选择脑卒中138例,其中脑出血组46例,脑梗死组62例,蛛网膜下腔出血组30例。病例依病情轻重、病灶大小、病程、伴发病积分、有无高血压史等分组,选择28例健康查体者作为对照组。用放免法检测血浆NT浓度。结果:脑梗死组NT水平(467.31±363.42)ng/L显著高于对照组(76.54±59.53)ng/L(t=4.638,P<0.0001),于发病后24h内显著升高(228.10±123.13)ng/L,4～7d达高峰(648.01±337.38)ng/L,8～15d开始下降(525.67±264.11)ng/L,15d后仍在较高水平(392.57±262.35)ng/L;重型(762.91±446.0)ng/L与大灶组(404.39±206.49)ng/L显著高于轻型(153.86±130.47)ng/L与小灶组(200.27±137.64)ng/L(P<0.01),伴发病积分≥6分组NT水平(623.11±377.97)ng/L显著高于<6分组(236.74±132.22)ng/L(t=3.506,P<0.001),高血糖组NT水平(673.26±331.00)ng/L显著高于正常血糖组(328.16±216.69)ng/L(t=
Objective: To observe the changes of plasma neurotensin (NT) and its dynamic changes in patients with cerebral hemorrhage, cerebral infarction and subarachnoid hemorrhage and to explore the pathophysiological mechanism of NT involved in various types of stroke and its accompanying diseases Significance of functional prognosis assessment. METHODS: The experiment was performed at the Department of Neurology, Jinan Great Wall Hospital, Department of Neurology, Second Affiliated Hospital of Shandong University, Shandong Provincial Hospital, Department of Neurology, Qilu Hospital of Shandong University and Institute of Microcirculation of Taishan Medical College from March 2002 to September 2003. 138 cases were selected stroke, including 46 cases of cerebral hemorrhage, cerebral infarction group 62 cases, 30 cases of subarachnoid hemorrhage group. According to the severity of the disease, the size of the lesion, the course of the disease, with the integral of the disease, the history of hypertension, etc., 28 healthy people were selected as the control group. Plasma concentration of NT was detected by radioimmunoassay. Results: The NT level in cerebral infarction group (467.31 ± 363.42 ng / L) was significantly higher than that in control group (76.54 ± 59.53) ng / L (t = 4.638, P <0.0001) (645.01 ± 337.38) ng / L at 4 ~ 7d, 525.67 ± 264.11ng / L at 8 ~ 15d, and 392.57 ± 262.35ng / L after 15d. (762.91 ± 446.0) ng / L and the large group (404.39 ± 206.49) ng / L were significantly higher than those of the mild group (153.86 ± 130.47ng ng / L and 200.27 ± 137.64ng ng / L, P0.01) The level of NT in patients with points ≥ 6 was significantly higher than that in patients with <6 (236.74 ± 132.22) ng / L (t = 3.506, P <0.001) L was significantly higher than the normal blood glucose group (328.16 ± 216.69) ng / L (t =