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目的通过对血清降钙素原(PCT)、超敏C反应蛋白(hs-CRP)水平的检测,探讨两者在幼年特发性关节炎(JIA)患儿诊断中的价值。方法采用免疫荧光层析法和免疫比浊法,检测并比较35例JIA合并细菌感染的患儿、23例JIA疑似病毒感染的患儿和27例JIA活动不伴感染的患儿血清PCT与hs-CRP水平。结果 JIA合并细菌感染组血清PCT与hs-CRP检测水平均明显高于JIA疑似病毒感染组和JIA活动不伴感染组,差异有统计学意义(P<0.05);JIA疑似病毒感染组和JIA活动不伴感染组比较,差异无统计学意义(P>0.05);JIA合并细菌感染组治疗后血清PCT与hs-CRP水平较治疗前显著降低(P<0.05)。结论血清PCT与hs-CRP水平可作为诊断JIA合并细菌感染的重要监测指标。
Objective To evaluate the value of serum procalcitonin (PCT) and hs-CRP in the diagnosis of juvenile idiopathic arthritis (JIA). Methods Immunofluorescence assay and immunoturbidimetry were used to detect and compare the serum levels of PCT and hs in 35 children with JIA complicated with bacterial infection, 23 children with JIA suspected infection and 27 children without JIA activity infection -CRP level. Results The levels of serum PCT and hs-CRP in JIA combined bacterial infection group were significantly higher than those in JIA suspected JIA infection group and JIA non-infected group (P <0.05). JIA suspected viral infection group and JIA activity The levels of PCT and hs-CRP in patients with JIA combined with bacterial infection were significantly lower than those before treatment (P <0.05). There was no significant difference between the two groups (P> 0.05). Conclusion Serum PCT and hs-CRP levels can be used as an important indicator in the diagnosis of bacterial infection of JIA.