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目的探讨辛伐他汀对动脉粥样硬化(AS)患者血清瘦素、高敏C反应蛋白(hs-CRP)和一氧化氮(NO)水平的影响。方法选取颈动脉粥样硬化患者62例为观察组,选取该期间到海南医学院附属医院健康体检人员110名为对照组,同时检测血浆瘦素(LP)、血脂水平、hs-CRP、NO和内皮素-1(ET-1),给予AS患者服用辛伐他汀40 mg,1次/d,观察并分析服用前及服药后3个月和6个月后上述指标的变化。结果 AS组患者除TC、低密度脂蛋白(LDL-C)增高外,血清瘦素水平Lp、hs-CRP和ET-1水平均大于正常对照组,而NO水平低于对照组;AS患者在应用辛伐他汀40 mg,1次/d,治疗后与治疗前相比,血清瘦素、LDL-C、hs-CRP和ET-1水平显著下降(P<0.01),而血清NO浓度明显上升(P<0.05)。结论辛伐他汀在降低LDL-C的同时,还可降低血清瘦素、hs-CRP,升高NO浓度,多重机制干预AS的进展。尽早使用他汀类药物有助于延缓AS的发展,降低动脉硬化性心血管疾病的风险。
Objective To investigate the effects of simvastatin on serum leptin, high-sensitivity C-reactive protein (hs-CRP) and nitric oxide (NO) in patients with atherosclerosis (AS) Methods Sixty-two patients with carotid atherosclerosis were selected as the observation group. One hundred and seventy healthy physical examination staffs of Affiliated Hospital of Hainan Medical College were selected as the control group. Plasma leptin (LP), blood lipid, hs-CRP, NO and ET-1, AS patients were given simvastatin 40 mg once a day, before and after taking the medication and 3 months and 6 months after the above indicators changes. Results The levels of serum leptin, Lp, hs-CRP and ET-1 in AS group were significantly higher than those in control group, while the levels of NO were lower than those in control group except TC and LDL-C. Compared with before treatment, the levels of serum leptin, LDL-C, hs-CRP and ET-1 were significantly decreased (P <0.01), while the serum NO concentration was significantly increased after simvastatin 40 mg, once daily (P <0.05). Conclusions Simvastatin can decrease serum leptin, hs-CRP, increase NO concentration and decrease the LDL-C level. Early use of statins can delay the development of AS and reduce the risk of arteriosclerotic cardiovascular disease.