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目的:探讨坎地沙坦与氨氯地平联合用药治疗社区老年原发高血压合并糖尿病患者的临床疗效。方法:选取80例社区老年原发高血压并糖尿病患者展开研究,采用随机分配的方法将其分为观察组(n=40)与对照组(n=40),观察两组患者的收缩压、舒张压及尿清蛋白情况。结果:观察组患者降压效果明显优于对照组,且观察组空腹血糖、糖化血红蛋白比对照组低,差异存在统计学意义P<0.05)。观察组(2.5%)与对照组(7.5%)患者不良反应发生率并无统计学差异(P>0.05)。结论:社区老年原发高血压合并糖尿病患者采用坎地沙坦联合氨氯地平治疗,能合理控制患者的血压并保护其肾功能,提升患者的治疗效果。
Objective: To investigate the clinical efficacy of candesartan combined with amlodipine in the treatment of elderly patients with hypertension in the community. Methods: Eighty elderly patients with essential hypertension and diabetes mellitus were enrolled in this study. Patients were randomly divided into observation group (n = 40) and control group (n = 40). The systolic blood pressure, Diastolic blood pressure and urinary albumin situation. Results: The antihypertensive effect of the observation group was significantly better than that of the control group, and the fasting blood glucose and glycosylated hemoglobin in the observation group were lower than those in the control group, with statistical significance (P <0.05). There was no significant difference in adverse reactions between the observation group (2.5%) and the control group (7.5%) (P> 0.05). CONCLUSION: Candesartan and amlodipine can be used in elderly patients with essential hypertension complicated with diabetes mellitus in the community to control the patient’s blood pressure and protect their renal function and improve the therapeutic effect.