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目的:研究粉防己碱(Tet)对豚鼠离体气管/支气管的感觉神经C纤维兴奋的抑制作用.方法:记录电场刺激所致的C纤维兴奋所产生的标本收缩(phase Ⅱ)张力,了解Tet的作用.结果:Tet 0.3—30 μmol·L~(-1)抑制phase Ⅱ收缩,在气管/支气管上,Tet 1 μmol·L~(-1)的抑制率分别是:40±38％和75±22％;用氯苯那敏或阿托品作用后,Tet 1 μmol·L~(-1)的抑制率分别是70±16％和64±16％;Tet不抑制外源性P物质引起的标本收缩.结论:Tet 1μmol·L~(-1)抑制豚鼠离体气道收缩的机理与其抑制感觉神经C纤维兴奋释放神经肽的作用有关.
Objective: To study the inhibitory effect of tetrandrine (Tet) on the activation of sensory nerve C fibers in isolated trachea/bronchiole of guinea pigs. Method: Record the phase II tension of C fiber excitation caused by electric field stimulation, and learn about Tet. Effects: Tet 0.3–30 μmol·L -1 inhibited phase II contraction. In the trachea/bronchi, the inhibition rates of Tet 1 μmol·L -1 were 40±38% and 75, respectively. ±22%; After treated with chlorpheniramine or atropine, the inhibition rates of Tet 1 μmol·L -1 were 70±16% and 64±16%, respectively; Tet did not inhibit the specimens caused by exogenous substance P Contraction. Conclusion: The mechanism of Tet 1μmol·L -1 inhibiting isolated airway contraction in guinea pigs is related to its inhibitory effect on the neuropeptide release.