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喹诺酮类药物是发展快、应用广、深受欢迎的新一代合成抗生素类药物,具有广谱、高效、低毒、易吸收、组织分布广及细胞内渗透性强等特点,临床使用十分普遍。笔者对此类药物在临床应用中应注意的问题简述如下。 1.抗菌谱 哇诺酮类药物对肠杆菌具有极佳活性,对绿脓杆菌和金葡菌有良好活性,在极低浓度下仍可抑制嗜血菌和淋球菌属细菌。对链球菌和厌氧菌,特别是拟杆菌属,则抑菌活性各不相同,因此,要
Quinolones are fast-developing, widely used and popular new generation of synthetic antibiotics, with broad spectrum, high efficiency, low toxicity, easy absorption, wide distribution of tissues and strong intracellular permeability. Clinical use is very common. The author of these drugs should pay attention to the problems in clinical applications are summarized as follows. 1. Antibacterial spectrum Wandolones have excellent activity against Enterobacteriaceae and have good activity against Pseudomonas aeruginosa and Staphylococcus aureus, and can still inhibit Haemophilus and Neisseria gonorrhoeae bacteria even under very low concentrations. Streptococcus and anaerobic bacteria, especially Bacteroides, the antibacterial activity varies, therefore, to