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目的 分析正常范围内的不同血糖水平对新生儿缺氧缺血性脑病 (HIE)预后的影响 ,探讨改善预后的措施。方法 对收治正常范围内的不同血糖水平的 16 1例HIE患儿临床资料及随访结果进行分析。结果 高血糖水平的HIE组 (高值组 )疗效显著高于低血糖水平的HIE组 (低值组 ) ,χ2 =4 0 33,P <0 0 5 ;且高值组预后显著优于低值组 ,χ2 =4 4 2 9,P <0 0 5 ;而中度血糖水平的HIE组 (中值组 )与低值组比较 ,无论是疗效 (χ2 =0 0 79,P >0 0 5 )还是预后 (χ2 =0 0 2 0 1,P >0 0 5 )其差异均无显著性。结论 早期诊治 ,维持内环境稳定 ,尤其是保持血糖水平在正常的高值是提高HIE患儿疗效、改善其预后的重要方法之一。
Objective To analyze the influence of different blood glucose levels in the normal range on the prognosis of neonates with hypoxic-ischemic encephalopathy (HIE) and to explore the measures to improve the prognosis. Methods The clinical data and follow-up results of 16 1 HIE children who received different blood glucose levels within the normal range were analyzed. Results The HIE group (high value group) with hyperglycemia was significantly more effective than hypoglycemic HIE group (low value group) (χ2 = 4033, P <0.05), and the prognosis of high value group was significantly better than that of low value group Group (χ2 = 4 4 2 9, P <0.05). However, no significant difference was found between the HIE group (median group) and low value group (χ2 = 0 0 79, P 0 05) Or prognosis (χ2 = 0 0 2 0 1, P> 0 0 5) the difference was not significant. Conclusion Early diagnosis and treatment to maintain the stability of the internal environment, in particular, to maintain normal high blood sugar levels is to improve the efficacy of HIE children to improve the prognosis of one of the important ways.