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一例13岁女孩,患慢性进行性肝炎、坏死后性肝硬变,溃疡性结肠炎、并有血凝固缺损。其身上产生一种抗体,尤其能干扰纤维蛋白形成。病人的净化纤维蛋白原功能正常,然而该抗体能抑制纤维蛋白的自身聚合,并使病人血浆纤维蛋白酶凝固时间延长。这种抗体具有免疫球蛋白 IgG 类的特性。在离子交换色谱法中,它与 IgG 成分一同洗脱,估计其分子量约为145,000道尔顿(dalton)。用光散射试验来测定该抗体对纤维蛋白聚合作用的影响,发现其迟滞时间延长,聚合作用曲线斜坡下降。这表明由于存在该抗体而使纤维蛋白单体的聚合大为延迟(p<0.01)。当然,对于本病人产生纤维蛋白原的抗体,不能
A 13-year-old girl with chronic progressive hepatitis, post-necrotic cirrhosis, ulcerative colitis, and blood coagulation defects. It produces an antibody that interferes with fibrin formation. The patient’s normalized fibrinogen function is normal, however, the antibody inhibits the self-polymerization of fibrin and prolongs the patient’s plasma fibrin clotting time. This antibody has the characteristics of immunoglobulin IgG class. In ion exchange chromatography, it elutes with the IgG component and is estimated to have a molecular weight of about 145,000 daltons. The effect of this antibody on fibrin polymerization was determined by light scattering test and found that the lag time was prolonged and the slope of the polymerization curve was decreased. This indicates that the polymerization of fibrin monomers is greatly delayed due to the presence of this antibody (p <0.01). Of course, for this patient to produce fibrinogen antibodies, can not