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【目的】从临床表现、肠镜及肠道菌群变化多方面对双歧杆菌三联活菌胶囊联合美沙拉嗪治疗溃疡性结肠炎疗效进行评价。【方法】选择本院92例溃疡性结肠炎采用数字表随机法分为两组，每组46例。对照组给予美沙拉嗪治疗，观察组在对照组基础上加用双歧杆菌三联活菌胶囊治疗，比较两组治疗前后临床症状总积分、肠道菌群、肠镜分级变化。【结果】观察组总有效率89．13％；对照组总有效率58．7％，观察组疗效明显优于对照组（P ＜0．05）。观察组治疗后症状评分、肠镜评分降低幅度大于对照组（P ＜0．05）。治疗后观察组乳酸杆菌、双歧杆菌数量明显增加，大肠杆菌、肠球菌数量明显下降（ P ＜0．05）。【结论】双歧杆菌三联活菌胶囊联合美沙拉嗪治疗溃疡性结肠炎有助于患者肠道菌群的平衡，从而达到抑制炎症的目的，显著提高疗效。“,”[Objective] To evaluate the efficacy of bifid triple viable capsule combined with mesalazine in the treatment of ulcerative colitis in many aspects of clinical manifestation ,colonoscopy and the changes of intestinal flora .[Methods]Totally 92 patients with ulcerative colitis patients in our hospital were divided into two groups by random digital table classification .The control group was given mesalazine only ,while the observation group was given mesalazine combined with bifid triple viable capsule .Clinical symptom scores ,intestinal flora and colonosco-py scores before and after the treatment were compared between two groups .[Results]The total effective rate of the observation group and control group was 89 .13% and 58 .7% ,respectively .The efficacy of observation group was obviously better than the control group ( P <0 .05) .After the treatment ,the decreasing degree of symptom scores and colonoscopy scores in observation group was larger than that in control group ( P<0 .05) .The number of lactobacillus and bifid bacterium in observation group after treatment were increased obviously ,but the number of Escherichia coli and Enterococcus were decreased obviously ( P<0 .05) .[Conclusion]Bifid triple viable capsule combined with mesalazine is benefit for the balance of intestinal flora ,and thus can inhibit the inflammation and significantly improve the curative effect .