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目的：研究反式曲马多对映体：（＋ ）反式曲马多和（ － ）反式曲马多的人体药代动力学。方法：１２ 名受试者ｐｏ 多剂量盐酸反式曲马多缓释片，用高效毛细管电泳法测定人血清中反式曲马多对映体的浓度，配对ｔ检验比较两对映体的血药浓度和药代动力学参数。结果：血药浓度达稳态后不同时间血清中（ ＋ ）反式曲马多的浓度均明显高于（ －）反式曲马多的浓度，两对映体的Ｃｍａｘ ，Ｃｍｉｎ ，Ｃａｖ，ＡＵＣ０ →∞，Ｔ１／２ 等药代动力学参数均有显著性差异。结论：人体对（＋ ）反式曲马多比对（ －）反式曲马多吸收完全、消除慢，反式曲马多对映体有药代动力学立体选择性。
OBJECTIVE: To study human pharmacokinetics of trans-tramadol enantiomers: (+) trans-tramadol and (-) trans-tramadol. Methods: Twelve subjects were given po multi-dose trans-tramadol hydrochloride sustained release tablets. The concentration of trans-tramadol in human serum was determined by high performance capillary electrophoresis. The t-test was used to compare the two enantiomers Blood concentration and pharmacokinetic parameters. Results: The concentrations of (+) - trans-tramadol in serum at different time after the steady-state plasma concentrations were significantly higher than those of (-) - trans-tramadol. The Cmax, Cmin, Cav , AUC0 → ∞, T1 / 2 and other pharmacokinetic parameters were significantly different. CONCLUSION: The human body is completely abolished by (+) - trans-tramadol (-) - trans-tramadol and has the pharmacokinetic stereoselectivity of eliminating the slow and trans-tramadol enantiomers.