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目的 探讨多发性骨髓瘤(MM)患者骨损害程度与肝细胞生长因子(HGF)血清浓度的关系。方法 采 用双抗体夹心酶联免疫吸附法检测32例MM患者的HGF血清浓度,观察其与多发性骨髓瘤骨损害的关系。结果 不同程度骨损害的MM患者,其血清HGF浓度的差异有统计学意义(P<0.01);MM骨损害越严重,其血清HGF 浓度增高越显著。结论 MM患者HGF血清浓度与骨损害程度有关,骨损害程度严重者,HGF血清浓度明显增高。
Objective To investigate the relationship between bone damage and serum concentration of hepatocyte growth factor (HGF) in patients with multiple myeloma (MM). Methods The serum levels of HGF in 32 patients with MM were detected by double antibody sandwich enzyme-linked immunosorbent assay (ELISA), and their relationship with bone lesions of multiple myeloma was observed. Results There was a significant difference in serum HGF concentration between MM patients with varying degrees of bone damage (P <0.01). The more severe MM bone damage was, the more significant the serum HGF concentration was increased. Conclusion The serum concentration of HGF in MM patients is related to the degree of bone damage. Serum levels of HGF in patients with severe bone damage are significantly higher.