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晚近曾有人提出抗心脂抗体(aCL)与偏头痛有关。本文采用前瞻性方法,探讨了系统性红斑狼疮(SLE)时aCL 与偏头痛间的可能联系。研究组包括SLE 病人103例(女86,男17;平均年龄38岁),对照组为58例非SLE 的偏头痛患者。SLE 中54例(52%)自述有频发的头痛,计偏头痛32例,紧张性头痛21例及丛集性头痛1例。偏头痛发作每次平均持续18小时,间隔23天。伴/不伴偏头痛的SLE 病人之性别,年龄,家族史和SLE 表现无显著差异。共30例(29%)有aCL。合并偏头痛者中5例有aCL,27例无aCL(17%:37%,P=0.07)。有/无aCL 者的偏头痛特征无显著差异。本文对照组中均未发现aCL。
It has recently been suggested that anti-lipoidal antibodies (aCL) are associated with migraine. This article uses a prospective approach to explore the possible link between aCL and migraine during systemic lupus erythematosus (SLE). The study group included 103 SLE patients (86 females, 17 males; mean age 38 years) and 58 non-SLE migraine sufferers in the control arm. Fifty-four (52%) SLE reported recurrent headaches, including 32 migraine headaches, 21 tension headaches and 1 cluster headache. Migraine attacks last for an average of 18 hours with an interval of 23 days. There were no significant differences in gender, age, family history, and SLE with SLE with / without migraine. A total of 30 patients (29%) had aCL. Among the patients with migraine, 5 had aCL and 27 had no aCL (17% vs 37%, P = 0.07). There was no significant difference in migraine characteristics between those with and without aCL. In this paper, no aCL was found in the control group.