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随着分子和细胞心脏病学知识的进展,基因治疗在心脏疾病治疗中的应用已经成为研究的热点和方向,很多预临床试验都已经取得了一定成功,而且规定了超声介导基因转染(ultrasound-mediated gene delivery, UMGD)的基本原则.但是,其应用在人体疾病治疗中存在多重障碍.随着微泡技术的发展和转染多种基因能力的增强,UMGD在未来可能成为心血管疾病基因治疗的一种有效的非侵入性技术.本文就超声介导基因转染在心血管疾病治疗应用中的基本原则、应用和对未来的展望与不足作一综述.“,”With the development of molecular and cellar cardiology,gene therapy to cardiovascular disease has become the hot spot and the direction of study.Now,preclinical studies on ultrasound-mediated gene delivery (UMGD) in cardiovascular disease have achieved some success,but it is still hindered by a series of practical challenges for clinical translation.Even so,UMGD still holds the promise to cardiovascular disease in gene therapy for its non-invasiveness,accuracy,safety and ability to deliver multiple genes with repeated deliveries.In this review,we will focus on the basic principle,the current development,the future prospect and drawbacks of UMGD in the therapeutic applications of cardiovascular disease.