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应用全自动图像分析仪对正常胃粘膜、残胃粘膜术后0～5年、6～10年及10年以上重度异型增生和胃癌进行了细胞形态、DNA含量和倍体分布测定.结果发现:残胃粘膜随术后时间的延长,其细胞形态、DNA含量和倍体分布也发生相应变化.以术后10年以上残胃粘膜变化较为显著.和真正的癌前病变—重度异型增生比较,DNA含量、倍体分布均无显著性差异.和胃癌比较:已具有癌细胞的一些病理特征.作者认为:凡残胃粘膜出现了异型增生、DNA含量增高和多倍体细胞,应警惕癌变的可能.
The cell morphology, DNA content, and ploidy distribution of normal dysplasia and gastric cancer after 0-5 years, 6-10 years, and more than 10 years after operation were measured by using automatic image analyzer. The results showed that: With the prolongation of the postoperative time, the residual gastric mucosa has corresponding changes in cell morphology, DNA content, and ploidy distribution. The residual gastric mucosa changes more than 10 years after surgery. Compared with true precancerous lesions, severe dysplasia, There was no significant difference in DNA content and ploidy distribution. Compared with gastric cancer, there were some pathological features of cancer cells. The authors believe that: Where there is dysplasia, DNA content and polyploid cells in the residual gastric mucosa, it should be alert to cancerous may.