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目的:研究柳氮磺胺嘧啶(SASP)和甲氨喋呤(MTX)联合治疗类风湿关节炎(RA)的疗效,并与单用甲氨喋呤治疗进行对照。方法:56例活动性RA病人分别用MTX(10mg/周)和MTX(10mg/周)加SASPO.5(3次/日)治疗,疗程为12个月,对两药在2月和12月时的疗效及观察指标进行评估。结果:临床缓解、显效、有效和无效的发生率在联合治疗组分别为30.8%、42.3%、15.3%和11.6%,在MTX组分别为26.7%、26.7%、16.6%和30.0%,显示联合治疗对RA的疗效优于单一MTX治疗(P<0.05),副作用的发生率分别是23.1%和16.6%(P>0.05)。结论:SASP+ MTX联合治疗活动性RA效果优于单一用MTX治疗。
Objective: To investigate the curative effect of combination of sulfasalazine (SASP) and methotrexate (MTX) on rheumatoid arthritis (RA) and to compare with methotrexate alone. METHODS: Fifty-six patients with active RA were treated with MTX (10 mg / week) and MTX (10 mg / week) plus SASPO.5 (3 times daily) for 12 months. The two drugs were administered in February and December When the efficacy and observation indicators to assess. Results: The rates of clinical remission, effective, effective and ineffective were 30.8%, 42.3%, 15.3% and 11.6% in the combined treatment group and 26.7%, 26.7%, 16.6% and 30.0% in the MTX group, respectively The efficacy of treatment on RA was superior to that of single MTX treatment (P <0.05). The incidence of side effects was 23.1% and 16.6%, respectively (P> 0.05). Conclusion: SASP + MTX combined with active RA is better than MTX alone.