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目的探讨糖尿病合并周围神经病变(DPN)患者血小板平均体积变化的临床意义。方法选取2型糖尿病(T2DM)患者197例,其中未合并周围神经病变者(T2DM组)89例,T2DM合并周围神经病变者(DPN组)108例,测定两组患者身高、体质量、血压、体质量指数(BMI)、空腹血糖(FBG)、糖化血红蛋白(Hb A1c)、血小板平均体积(MPV)、血小板计数(PLT)、红细胞平均宽度(PCT)、血小板容积比(PDW)。结果 DPN组血清MPV水平高于T2DM组,差异有统计学意义(P<0.05)。Logistic多元逐步回归分析显示,年龄、MPV水平升高可增加T2DM患者DPN风险。结论血清MPV水平与DPN发生关系密切。
Objective To investigate the clinical significance of platelet mean volume changes in diabetic patients with peripheral neuropathy (DPN). Methods A total of 197 patients with type 2 diabetes mellitus (T2DM) were enrolled. Among them, 89 patients with T2DM and T2DM with peripheral neuropathy (DPN) were included in this study. Height, body weight, blood pressure, BMI, FBG, Hb A1c, MPV, PLT, PCT, PDW were measured. Results The level of serum MPV in DPN group was higher than that in T2DM group, the difference was statistically significant (P <0.05). Logistic multivariate stepwise regression analysis showed that age and MPV levels increased the risk of DPN in T2DM patients. Conclusion Serum MPV levels are closely related to the occurrence of DPN.