论文部分内容阅读
磺胺嘧啶(SD)是临床上常用的抗感染药物,过去对它的动力学研究不够,每日用药次数多(4～6次),用量大(成人4～6克/日),毒副反应发生率高。后发现SD属于排泄较慢的中效磺胺,改变其给药方案,减少了给药次数和剂量,不仅保证了疗效,而且减少了副作用。近几年出版的书刊,所载的给药方案不尽相同,有的是成人1克/次,2次/日,首量加倍:有的是成人0.5～1克/次,1～2次/日,首量加倍。本文根据药物动力学原理,讨论SD的合理给药方案。
Sulfadiazine (SD) is a clinically used anti-infective drug. In the past, the kinetics of sulfadiazine (SD) was not enough. The daily dosage of sulfadiazine (4-6 times) High incidence. After SD was found to be slower excretion of sulfonamide, change its dosing regimen, reducing the frequency and dose administration, not only to ensure the efficacy, but also reduce the side effects. The books and periodicals published in recent years contain different dosage regimens, some are 1g / time for adults and 2 times / day for adults. The first dose is doubled: some are 0.5-1g / time, 1-2 times / day for adults, Double the amount. This article based on the pharmacokinetic theory, to discuss the rational delivery of SD program.