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RU 486经口服、皮下、肌肉和阴道四种途径给药,对大鼠有显著的抗早孕作用;幼兔子宫内膜增生试验证明其在大剂量时有明显的抗孕酮活性;大鼠子宫体外孕激素胞浆受体结合力试验证明与孕酮受体有很强的结合能力。此外还进行了血浆药物半衰期及急性毒性测定。
Administration of RU 486 orally, subcutaneously, intramuscularly and vaginally has significant anti-pregnancy effect on rats. In rabbits, endometrial hyperplasia test shows that it has obvious anti-progesterone activity at high dose. In vitro progesterone cytoplasmic receptor binding test progesterone receptor with strong binding capacity. In addition, plasma drug half-life and acute toxicity were also determined.