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目的 :探讨白细胞介素 6 (IL 6 )、C 反应蛋白 (CRP)、纤维蛋白原 (Fg)及肺炎衣原体 (Cpn)感染与冠心病 (CHD)间的关系。方法 :急性心肌梗死 (AMI)组、经冠状动脉造影证实的心绞痛 (AP)组及正常对照各 30例。应用放射免疫法检测血清IL 6浓度 ,散射免疫浊度法检测血浆Fg及血清CRP水平 ,并用微量免疫荧光法检测血清Cpn特异性抗体IgG、IgM滴度并检测呼吸道合胞病毒特异性抗体IgG滴度做对照。 结果 :AMI组和AP组的血清IL 6、CRP及血浆Fg水平显著高于对照组 (均P<0 .0 1)。血清IL 6、CRP及血浆Fg水平彼此显著相关 (r值分别为 0 .81、0 .80和 0 .6 8,均P <0 .0 1) ,三者水平与AP患者的冠状动脉狭窄危险分数相关。AMI组、AP组血清抗CpnIgG抗体阳性率显著高于对照组 (分别 P <0 .0 1、<0 .0 5 )。三组的Cpn特异性IgM抗体与抗呼吸道合胞病毒IgG抗体阳性率比较差异无显著性意义。抗CpnIgG抗体阳性者IL 6、CRP水平显著高于阴性者。Cpn感染者特异性抗体IgG滴度与血中IL 6、CRP及Fg水平均明显相关。 结论 :炎性细胞因子及其诱生的急性相蛋白与CHD发生发展密切相关 ,炎症反应强度可能反映CHD病变程度。Cpn慢性感染与CHD相关 ,并可能通过介导炎症反应参与CHD发生发展
Objective: To investigate the relationship between interleukin 6 (IL 6), C reactive protein (CRP), fibrinogen (Fg) and Cpn infection and coronary heart disease (CHD). Methods: Acute myocardial infarction (AMI) group, angina pectoris (AP) group confirmed by coronary angiography (AP) and normal control group of 30 cases. Serum IL-6 levels were measured by radioimmunoassay, plasma Fg and serum CRP levels were measured by immunofluorescence assay. Serum Cpn-specific IgG and IgM titers were detected by micro-immunofluorescence assay, and respiratory syncytial virus-specific antibody IgG was detected Degree contrast. Results: Serum levels of IL-6, CRP and plasma Fg in AMI group and AP group were significantly higher than those in control group (all P <0.01). Serum IL 6, CRP and plasma Fg levels were significantly correlated with each other (r values were 0.81, 0.80 and 0.68, respectively, P <0.01), the three levels and AP risk of coronary artery stenosis Score related. The positive rate of anti-Cpn IgG antibody in AMI group and AP group was significantly higher than that in control group (P <0.01, <0.05, respectively). There was no significant difference in the positive rates of Cpn-specific IgM antibodies and anti-respiratory syncytial virus IgG antibodies among the three groups. Anti-Cpn IgG antibody positive IL 6, CRP levels were significantly higher than negative. Cpn-infected patients with specific antibody IgG titers and blood IL 6, CRP and Fg levels were significantly related. Conclusion: Inflammatory cytokines and its induced acute phase proteins are closely related to the occurrence and development of CHD. The severity of inflammatory reaction may reflect the severity of CHD. Chronic CPn infection is associated with CHD and may be involved in the development of CHD by mediating inflammatory reactions