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口服避孕药(OC)不但是最有效的节育方法,而且由于含有有效的口服速效的孕激素和雌激素,还有其它有益健康的优点。由于是在月经周期开始的5天每天服用这种药物和内源性雌二醇的分泌受到明显的抑制,因而在这时期雌激素的靶组织受不到雌激素的刺激。在正常的排卵月经周期中,在LH高峰前,卵巢不分泌足量的孕酮。当LH增多时,类固醇的生物合成由Δ5径路变成Δ4径路。因而,在滤泡期,卵巢分泌的雌激素量逐渐增加,而孕酮很少。子宫内膜的腺体和基质显著增生,从而加速了子宫内膜的生成。在黄体期,卵巢继续分泌雌激素,而且
Oral contraceptives (OCs) are not only the most effective method of birth control but also have other health benefits due to their potent orally available progestins and estrogens. Since the daily administration of this drug and the secretion of endogenous estradiol were significantly inhibited 5 days after the beginning of the menstrual cycle, the estrogen target tissues were not stimulated by estrogen during this period. Ovaries do not secrete sufficient progesterone during normal ovulation menstrual cycles before LH peak. As LH increases, steroid biosynthesis changes from the Δ5 pathway to a Δ4 pathway. Thus, during the follicular phase, the amount of estrogen secreted by the ovary gradually increases, while progesterone is scarce. Endometrial glands and stroma significantly hyperplasia, thereby accelerating the formation of endometrium. In the luteal phase, the ovary continues to secrete estrogen, moreover