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为探讨CA125在肺癌诊断、鉴别诊断、分期中的应用，采用免疫放射分析法测定50例肺癌患者血清CA125水平，结果显示：肺癌患者血清CA125水平显著增高，其增高的程度与肺癌TNM分期直接相关，依次为IV期＞III期＞II期＞I期，其中鳞癌、腺癌、小细胞未分化癌患者血清CA125水平差异无显著性，以12U／ml为临界值，与正常对照组相比，血清CA125测定诊断肺癌的敏感度为67．4％，特异度100％；准确度84．27％；与脑部良性病变组比较，上述值分别为：67．4％，82．14％和71．83％。表明血清CA125测定对于肺癌的诊断、鉴别诊断和分期具有重要的意义。
In order to investigate the application of CA125 in the diagnosis, differential diagnosis and staging of lung cancer, the serum CA125 levels in 50 lung cancer patients were measured by immunoradiometric assay. The results showed that the serum CA125 level was significantly higher in lung cancer patients, and the increased degree was directly related to the TNM stage of lung cancer. In the order of IV>III>II>I, the serum CA125 levels in squamous cell carcinoma, adenocarcinoma, and small cell undifferentiated carcinoma had no significant difference, with 12 U/ml as the critical value, compared with the normal control group. The sensitivity of serum CA125 in the diagnosis of lung cancer was 67.4% and the specificity was 100%; the accuracy was 84.27%; compared with the benign brain disease group, the above values were: 67.4%, 82.14% and 71.83%. It is indicated that serum CA125 assay is of great significance for the diagnosis, differential diagnosis and staging of lung cancer.