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目的分析常州市武进区妊娠中期孕妇产前筛查结果。方法选择常州市武进区产前筛查的孕妇4062例,孕周15-20周,年龄20-41岁。应用时间分辨免疫荧光分析法,检测血清甲胎蛋白(AFP)、游离β-绒毛膜促性腺激素(β-HCG)、游离E3,结合孕妇年龄、孕周、体重等因素计算风险率,对高风险孕妇进行羊膜腔穿刺,羊水细胞染色体核型分析。结果 4062例中,筛查出高风险孕妇367例(9.03%),其中唐氏综合征高风险256例(6.30%),18-三体综合征高风险46例(1.13%),神经管缺陷36例(0.89%),年龄>35岁的29例(0.71%)。行羊膜腔穿刺300例,羊水细胞染色体检查发现异常核型6例,其中唐氏综合征3例,18-三体综合征2例,其他异常1例。结论孕中期孕妇进行无创伤性产前筛查,结合产前诊断,及时终止妊娠,可以减少出生缺陷,对优生工作具有重要意义。
Objective To analyze the prenatal screening results of pregnant women in Wujin District of Changzhou City during the second trimester of pregnancy. Methods 4062 pregnant women of prenatal screening in Wujin District of Changzhou City were selected. Their gestational age ranged from 15 to 20 weeks and their ages ranged from 20 to 41 years old. AFP, free β-HCG and free E3 were detected by time-resolved immunofluorescence assay. The risk factors were calculated according to the age, gestational age and body weight of pregnant women. Amniocentesis and amniotic fluid cell karyotype analysis in pregnant women at risk. Results A total of 3662 high-risk pregnant women (9.03%) were screened out of 4062 cases, of which 256 cases (6.30%) had Down’s syndrome, 46 cases (1.13%) had high risk of Trisomy 18, neural tube defects Thirty-six patients (0.89%) and 29 patients (> 0.71%) aged> 35 years old. There were 300 cases of amniocentesis by amniocentesis and 6 cases of abnormal karyotype by amniotic fluid cell chromosome examination. Among them, 3 were Down’s Syndrome, 2 were 18-trisomy syndrome and 1 was other abnormalities. Conclusion Pregnant women in the second trimester of non-invasive prenatal screening, combined with prenatal diagnosis, and timely termination of pregnancy, can reduce birth defects, eugenics is of great significance.