Inhibition of HIV-1 replication by intracellular expression of antisense polymeric TAR-Core RNAs

• 作 者: Longchuan Bai Jiangang Yuan
• 出 处: 中国实验血液学杂志
• 发表日期: 1997年3期
• 关键词: ANTISENSE POLYMERIC REPLICATION INTRACELLULAR template targeted RNA INHIBITION i

Objectives: To construct retroviral vectorsexpressing antisense polymeric RNAs targeted at the coresequence (+13-+47) of HIV-l TAR RNA, and to testthe anti-HIV properties of this construct in transducedCD4~+T cells. Methods: The polymeric TAR-Core DNAwas