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慢性心力衰竭是许多心血管疾病终末状态的表现,而低钠血症是慢性心力衰竭中最常见的电解质紊乱。大量循证医学证据表明低钠血症是慢性心力衰竭患者病死率及再次住院率的独立预测因子,而传统的治疗低钠血症的方法在慢性心力衰竭中应用效果不佳且不良反应较多。作为新一代的利尿剂,研究表明精氨酸加压素受体拮抗剂在纠正慢性心力衰竭患者的低钠血症中具有积极作用,现将对此进行综述。
Chronic heart failure is a manifestation of the terminal state of many cardiovascular diseases, and hyponatremia is the most common electrolyte disorder in chronic heart failure. A large body of evidence-based medical evidence suggests that hyponatremia is an independent predictor of mortality and rehospitalization in patients with chronic heart failure, whereas the traditional approach to treating hyponatremia is ineffective and has more adverse effects in chronic heart failure . As a new generation of diuretics, studies have shown that arginine vasopressin receptor antagonists have a positive effect in correcting hyponatremia in patients with chronic heart failure, which is now reviewed.