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作者采用肉汤二倍稀释法测定了 Cipr-ofloxacin 及万古霉素等六种抗生素对54株临床分离的耐甲氧西林金葡菌(MRSA)的最低抑菌浓度(MIC)和最低杀菌浓度(MBC)所有菌株对三个耐酶青霉素——甲氧西林、乙氧萘青霉素和苯唑青霉素全部耐药;许多菌株对庆大霉素也耐药;45%菌株对氯林霉素耐药;但全部菌株对 Ciprofloxacin 和万古霉素敏感。Ciprofloxacin 对这些 MRSA 的MIC_(50)为0.25μg/ml,MIC_(90)为0.5μg/ml。Ciprofloxacin 和万古霉素对所有被试菌呈现杀菌作用,MBC_(90)分别为1.0和2.0μg/ml。对15株 MRSA 杀菌动力学的研究指出,当接种菌量为5.0×10~5CFU/ml 时,Cipro-floxacin 和万古霉素的杀菌率没有显著不
The authors tested the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MIC) of 54 clinically isolated MRSA strains of six antibiotics, Cipr-ofloxacin and vancomycin, using the double dilution method of broth MBC) All strains were resistant to three isolates resistant to penicillin-methicillin, nafcillin and oxacillin; many strains were also resistant to gentamycin; 45% strains were resistant to clindamycin; However, all strains were sensitive to Ciprofloxacin and vancomycin. The MIC 50 of Ciprofloxacin against these MRSA was 0.25 μg / ml and the MIC 90 was 0.5 μg / ml. Ciprofloxacin and vancomycin showed bactericidal effect on all tested bacteria, with MBC 90 of 1.0 and 2.0 μg / ml, respectively. Studies on the bactericidal kinetics of 15 strains of MRSA indicated that the bactericidal rate of Cipro-floxacin and vancomycin was not significant when the inoculum size was 5.0 × 10 -5 CFU / ml