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氰联吡啶酮(milrinoenmil)是新近发现的具有强心、抗心律失常和降低外周血管阻力作用的新药。本工作观察它对去甲肾上腺素(NA)收缩的大鼠肠系膜微血管的作用。雄性Wistar大鼠肠系膜微血管经显微电视系统放大460倍后测量口径。按田中提出的七级标准观察血液流态。然后局部滴加10~(-5)～10~(-3)M NA至微血管明显收缩且血流停滞。再依次滴加浓度为0.4,4,40,400μg/ml的mil,再次用药2分钟后测定微血管口径及血液流态的变化。
Milrinoenmil is a newly discovered new drug with cardiotonic, anti-arrhythmic and anti-vascular resistance. This work observed its effect on norepinephrine (NA) contracted rat mesenteric microvasculature. Mesenteric capillaries of male Wistar rats were magnified 460 times and magnified by microscopic television system. According to Tanaka proposed seven levels of blood flow observation. Then local drip 10 ~ (-5) ~ 10 ~ (-3) M NA to microvascular contraction and blood flow stagnation. Then followed by dropping the concentration of 0.4,4,40,400μg / ml of mil, measured again after 2 minutes of administration of microvascular caliber and blood flow changes.