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随着药物代谢动力学的进展,抗癫痫药物血浓度的测定已应用于临床。由于监测血浓度,使发作的全控率有明显提高。本文根据自贡会议测定抗癫痫药物血浓度指征的规定,在连服苯巴比妥(PB)后的第6～8天,测其达稳态浓度,井追踪观察其疗效。观察对象和方法1.资料来源本组病例系1983～1984年我院儿科癫痫专病门诊确诊为癫痫者21例,其中男12例,女9例;大发作19例,小发作2例。起病年龄为8个月～14岁,病程从1个月～6年。全部病例均描记脑电
With the development of pharmacokinetics, the determination of anti-epileptic drugs blood concentration has been applied to clinical. Due to the monitoring of blood concentration, the overall rate of attack increased significantly. According to the provisions of Zigong meeting to determine the indication of antiepileptic drug blood concentration, after reaching the phenobarbital (PB) on the 6th to 8th day, the steady state concentration was measured and the effect was observed. Observations and methods 1. Data sources The group of patients from 1983 to 1984 pediatric epilepsy clinic diagnosed as epilepsy in 21 cases, including 12 males and 9 females; major episodes in 19 cases, 2 cases of small seizures. Age of onset is 8 months to 14 years old, duration from 1 month to 6 years. EEG was recorded in all cases