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目的探讨α-硫辛酸联合前列地尔治疗2型糖尿病周围神经病变(DPN)的临床疗效及安全性。方法将100例2型糖尿病周围神经病变患者随机分为两组,两组均严格控制饮食,给予降血糖、控制血压、调血脂等常规治疗。其中50例作为治疗组,给予静脉推注前列地尔注射液10μg及静脉滴注α-硫辛酸20 ml,均为1次/d,另50例作为对照组,给予静脉推注前列地尔注射液10μg,1次/d,疗程2周。比较两者治疗前后疗效、神经传导速度。结果治疗组总有效率(84.0%)显著高于对照组(60.0%,P<0.05),治疗组神经传导速度明显提高(P<0.05)。两组均未见明显不良反应。结论α-硫辛酸联合前列地尔治疗2型糖尿病周围神经病变有显著的疗效。
Objective To investigate the clinical efficacy and safety of α-lipoic acid combined with alprostadil in the treatment of type 2 diabetic peripheral neuropathy (DPN). Methods 100 cases of type 2 diabetic peripheral neuropathy patients were randomly divided into two groups, the two groups were strictly controlled diet, given hypoglycemic, control blood pressure, blood lipid and other conventional treatment. Among them, 50 patients were treated by intravenous injection of alprostadil 10μg and intravenous infusion of α-lipoic acid 20ml once a day, and the other 50 cases as control group. Intravenous bolus injection of prostaglandin Liquid 10μg, 1 time / d, treatment for 2 weeks. Compare the two before and after treatment efficacy, nerve conduction velocity. Results The total effective rate (84.0%) in the treatment group was significantly higher than that in the control group (60.0%, P <0.05). The nerve conduction velocity in the treatment group was significantly increased (P <0.05). No obvious adverse reactions were found in both groups. Conclusion α-lipoic acid combined with alprostadil treatment of type 2 diabetic peripheral neuropathy have a significant effect.