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目的探讨重组人α-2b干扰素凝胶联合微波治疗妊娠尖锐湿疣保胎者的临床疗效及预后。方法将60例妊娠合并尖锐湿疣保胎者随机分为对照组和治疗组,每组30例。对照组单纯予以微波治疗,治疗组予以微波联合重组人α-2b干扰素凝胶外用治疗,对尖锐湿疣治疗效果及妊娠结局进行分析。结果治疗组治愈率83.3%(25/30),复发率36.7%(11/30);对照组治愈率46.7%(14/30),复发率73.3%(22/30),两组比较差异有统计学意义(χ2=7.177,P=0.007)。两组均未见影响分娩及新生儿HPV感染的病例发生。结论妊娠合并尖锐湿疣保胎者应用重组人α-2b干扰素凝胶联合微波疗效确切,预防复发效果显著,有利于继续妊娠及正常分娩。
Objective To investigate the clinical efficacy and prognosis of recombinant human α-2b interferon gel combined with microwave in the treatment of congenital condyloma acuminatum. Methods Sixty pregnant women with condyloma acuminatum were randomly divided into control group and treatment group, 30 cases in each group. The control group was treated with microwave only. The treatment group was treated with microwave combined with recombinant human α-2b interferon gel, and the therapeutic effect of condyloma acuminatum and pregnancy outcome were analyzed. Results The cure rate was 83.3% (25/30) in the treatment group and the recurrence rate was 36.7% (11/30). The cure rate in the control group was 46.7% (14/30) and the recurrence rate was 73.3% (22/30) Statistical significance (χ2 = 7.177, P = 0.007). No cases of childbirth and neonatal HPV infection were seen in both groups. Conclusions Pregnancy combined condyloma acuminata pregnancy with recombinant human α-2b interferon gel combined with microwave curative effect, prevention of recurrence is significant, is conducive to the continuation of pregnancy and normal delivery.