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鉴于疟原虫对不少抗疟药产生抗性,迫使人们进一步寻求新的抗疟药物。N—甲基环叔胺基团的化合物有一定的抗疟作用,具有类似结构的利福平对小鼠约氏疟原虫、伯氏疟原虫高度抗氯喹株、食蟹猴疟原虫以及体外培养的恶性疟原虫均有一定的杀灭作用。据此,我们于1989年9～10月在安徽省六安县对间日疟患者用利福平进行了治疗,并用传统的氯喹/伯氨喹(氯一伯)疗法作对照。一、材料与方法1.治疗对象:具有间日疟临床症状、血检间日疟原虫阳性、半月内未用过抗疟药及病程在5d 以内的患者。利福平治疗组共21例,男13例、女8例;氯—伯组54
In view of the resistance of malaria parasites to many antimalarial drugs, people are urged to further seek new antimalarial drugs. The compound of the N-methyl tertiary amine group has some anti-malarial effect with rifampicin of similar structure on mouse P. yoelii, P. berghei highly chloroquine resistant strains, P. cynomolgus malaria parasite and in vitro culture Of Plasmodium falciparum have a certain killing effect. Based on this, we treated rifampicin against vivaxerum in Lu’an County, Anhui Province from September to October 1989 and compared it to conventional chloroquine / primaquine (Chlorhexine) therapy. First, the material and methods 1. The object of treatment: with the clinical symptoms of vivax malaria, blood plasma test positive for Plasmodium vivax, did not use anti-malaria drugs within half a month and duration of less than 5d patients. 21 cases of rifampin treatment group, 13 males and 8 females; chlorine - Bo group 54