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目的探讨胃镜下注射抗肿瘤药物及免疫增强剂在胃癌患者临床治疗中的应用效果。方法选取2013-01-2015-12济宁市第一人民医肿瘤科门诊收治入院的68例胃镜检查确诊的胃癌患者,随机分为两组,每组34例,对照组行常规全身化疗,观察组行胃镜下局注抗肿瘤药物及免疫增强剂,评估两组临床疗效并监测不良事件。结果观察组治疗总有效率明显高于对照组,且不良事件发生率显著低于对照组(64.7%vs 35.3%,17.6%vs 52.9%),差异有统计学意义,P<0.05。结论胃镜下注射抗肿瘤药物及免疫增强剂疗效较全身化疗更加理想,而且安全性高,值得临床推广。
Objective To investigate the application of endoscopic injection of antineoplastic agents and immune enhancers in the clinical treatment of patients with gastric cancer. Methods Sixty-six patients with gastric cancer diagnosed by endoscopy admitted to the First People’s Medical Oncology Clinic in Jining City from January 2013 to December 2015 were randomly divided into two groups, 34 cases in each group. The control group received conventional systemic chemotherapy and the observation group Under endoscopy, anti-tumor drugs and immunostimulants were injected to assess the clinical efficacy and monitor adverse events. Results The total effective rate of observation group was significantly higher than that of control group, and the incidence of adverse events was significantly lower than that of control group (64.7% vs 35.3%, 17.6% vs 52.9%, P <0.05). Conclusion The efficacy of endoscopic injection of anti-tumor drugs and immune enhancers is more ideal than systemic chemotherapy, and it is safe and worthy of clinical promotion.