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哺乳动物雷帕霉素靶蛋白（ mTOR）是细胞内许多重要信号转导通路的枢纽，参与多种生理与病理过程（如细胞增殖、细胞周期调控、细胞迁移等），其功能失调与肿瘤的发生、发展紧密相关。以mTOR为靶点的抗肿瘤基础研究已是当前热点。上皮间质转化（ EMT）与肿瘤的侵袭与转移密切相关，受多种转录因子以及Wnt、转化生长因子β、Notch等信号通路的调控。 mTOR结合蛋白、信号通路及相关基因均参与恶性肿瘤EMT进程， mTOR可正性调控EMT，改变肿瘤的侵袭与转移能力。“,”Mammalian target of rapamycin ( mTOR) is the hub of many important signaling pathways in cells,involved in many physiological and pathological processes,such as cell proliferation,cell cycle regulation,cell migration,etc.Disorded function of mTOR is closely associated with the occurrence and developmentof tumor.The basic research of anti-tumor targeting mTOR is the current hot spot.Epithelial-mesenchymaltransition(EMT) is closely related to the invasion and metastasis of tumor,which is controlled by manytranscription factors and Wnt,transforming growth factor βand Notch signaling pathways.Many studies havefound that mTOR binding protein,signal pathways and related genes are involved in malignant tumor EMTprocess,and mTOR can positively regulate EMT,and change the ability of invasion and metastasis of neoplasms.