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目的:观察子宫内膜癌患者血清人附睾蛋白4(HE4)和人软骨糖蛋白-39(HCgp-39)水平的变化及其临床意义。方法:选择本院于2014年1~6月收治的子宫内膜癌患者34例及同期健康体检人员34名作为研究对象,子宫内膜癌患者作为观察组,健康人员作为对照组,均测定2组患者血清人附睾蛋白4和人软骨糖蛋白-39水平,比较两组差异。结果:观察组血清人附睾蛋白4和人软骨糖蛋白-39水平分别为(98.5±22.8)pmol/L、(98.7±19.8)μg/L,均高于对照组(P<0.05)。子宫内膜癌早期组(临床分期Ⅰ~Ⅱ)及晚期组(Ⅲ~Ⅳ)HE4、HCgp-39水平均高于对照组,且晚期组水平高于早期组(P<0.05)。结论:子宫内膜癌患者血清人附睾蛋白、人软骨糖蛋白-39显著升高,且临床分期晚期患者其水平越高,具有重要临床价值。
Objective: To observe the changes of serum human epididymitis 4 (HE4) and human chondriosome glycoprotein-39 (HCgp-39) in patients with endometrial carcinoma and its clinical significance. Methods: 34 cases of endometrial cancer and 34 healthy people were enrolled in our hospital from January to June, 2014. The patients with endometrial cancer as the observation group and the healthy people as the control group, all of which were measured 2 The serum level of human epididymis 4 and human chondro-glycoprotein-39 were compared between the two groups. Results: The levels of human epididymal protein 4 and human chondro glycoprotein-39 in the observation group were (98.5 ± 22.8) pmol / L and (98.7 ± 19.8) μg / L, respectively, higher than those in the control group (P <0.05). The levels of HE4 and HCgp-39 in the early stage of endometrial carcinoma (clinical stages Ⅰ ~ Ⅱ) and the late stage (Ⅲ ~ Ⅳ) were higher than those in the control group, and the levels in the advanced stage were higher than those in the early stage (P <0.05). Conclusion: The serum human epididymitis, human chondro-glycoprotein-39 is significantly elevated in patients with endometrial cancer, and the higher the clinical stage of patients with advanced clinical stage, has important clinical value.