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目的:对于宫颈上皮内瘤变和宫颈鳞癌妇女,分析其发病与p16INK4A蛋白和HPV感染的相关性。方法:选取2013年4月~2014年6月发病后收治入该院的宫颈疾病患者172例作为研究对象,测定患者宫颈标本中p16INK4A蛋白的情况、HPV的感染率,分析p16INK4A蛋白表达与HPV感染的相关性及HPV感染的高危亚型。结果:p16INK4A蛋白表达的阳性率随宫颈病变程度加重而上升,HPV的感染率随宫颈病变程度加重而上升;p16INK4A蛋白表达的阳性率为62.79%,HPV感染率为45.35%,p16INK4A蛋白的表达与HPV感染具有相关性。CINⅢ级及宫颈鳞癌的病理符合率高。结论:在宫颈上皮内瘤变和宫颈鳞癌发病中,p16INK4A蛋白表达和HPV感染具有相关性,二者联合检测对宫颈癌患者的早期筛检具有重要作用,建议临床推广。
OBJECTIVE: To investigate the relationship between the pathogenesis of p16INK4A protein and HPV infection in cervical intraepithelial neoplasia and cervical squamous cell carcinoma. Methods: A total of 172 cases of cervical diseases admitted to our hospital from April 2013 to June 2014 were selected as study objects. The p16INK4A protein in cervical specimens and the HPV infection rate were analyzed. The expression of p16INK4A protein and HPV infection Relevance and high risk subtypes of HPV infection. Results: The positive rate of p16INK4A protein increased with the severity of cervical lesions. The infection rate of HPV increased with the severity of cervical lesions. The positive rate of p16INK4A protein was 62.79% and the HPV infection rate was 45.35%. The expression of p16INK4A protein was HPV infection is relevant. CIN Ⅲ and cervical squamous cell carcinoma consistent with the high rate. Conclusion: The expression of p16INK4A protein is associated with HPV infection in cervical intraepithelial neoplasia and cervical squamous cell carcinoma. The combined detection of p16INK4A and HPV16 has an important role in the early screening of patients with cervical cancer. It is suggested that clinical application should be promoted.