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目的比较不同剂量氯吡格雷在不稳定型心绞痛中的应用效果。方法随机选取2013年3月至2016年3月收治的不稳定型心绞痛患者80例,依据氯吡格雷使用剂量方法将这些患者分为两组,即较大剂量组(n=40)和较小剂量组(n=40),对两组患者的心绞痛发作频率、持续时间、临床疗效及不良心脏事件发生情况进行统计分析。结果较大剂量组患者的心绞痛发作频率显著低于较小剂量组(P<0.05),持续时间显著短于较小剂量组(P<0.05),治疗的总有效率92.5%(37/40)显著高于较小剂量组72.5%(29/40)(P<0.05),不良心脏事件发生率15.0%(6/40)显著低于较小剂量组30.0%(12/40)(P<0.05)。结论负荷剂量且短期内大量使用氯吡格雷在不稳定型心绞痛中的应用效果较较小剂量好。
Objective To compare the effect of different doses of clopidogrel in unstable angina pectoris. Methods Totally 80 patients with unstable angina pectoris were selected from March 2013 to March 2016. Patients were divided into two groups according to the dosage of clopidogrel, namely, the larger dose group (n = 40) and smaller Dose group (n = 40). The frequency of angina pectoris, duration, clinical efficacy and occurrence of adverse cardiac events in both groups were statistically analyzed. Results The frequency of angina pectoris in the higher dose group was significantly lower than that in the lower dose group (P <0.05), and the duration was significantly shorter than that in the lower dose group (P <0.05). The total effective rate was 92.5% (37/40) (P <0.05). The incidence of adverse cardiac events was 15.0% (6/40) significantly lower than that of the lower dose group (30.0%, 12/40) (P <0.05) ). Conclusion The use of clopidogrel in large doses in short-term and unstable angina pectoris is better than that of low-dose.