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目的:比较不同胰岛素给药方法对糖尿病酮症酸中毒(DKA)的治疗差异。方法:60例糖尿病酮症酸中毒患者随机分为胰岛素泵皮下输注组(CSII组,30例)和常规小剂量胰岛素静脉滴注组(IVI组,30例),观察2组患者血糖(空腹及餐后2 h血糖)的变化、尿酮体转阴时间、平均胰岛素用量及低血糖发生率的差异。结果:CSII组血糖达标时间、尿酮体转阴时间较IVI组明显缩短(P<0.01);平均胰岛素用量少于IVI组(P<0.05)。低血糖发生率明显低于IVI组(P<0.01)。治疗前、后空腹及餐后2 h血糖水平两组间差异无统计学意义(P>0.05)。结论:胰岛素泵治疗较常规小剂量胰岛素静脉滴注短期疗效更安全、有效。
Objective: To compare the therapeutic effects of different insulin dosage regimens on diabetic ketoacidosis (DKA). Methods: Sixty patients with diabetic ketoacidosis were randomly divided into subcutaneous insulin pump (CSII group, 30 cases) and conventional low-dose insulin intravenous drip group (IVI group, 30 cases). The blood glucose And 2 h postprandial blood glucose), urine ketone body turn over time, the average amount of insulin and the incidence of hypoglycemia. Results: The duration of blood glucose and urine ketone bodies in CSII group were significantly shorter than those in IVI group (P <0.01). The average insulin dosage was less than IVI group (P <0.05). The incidence of hypoglycemia was significantly lower than that of IVI group (P <0.01). There was no significant difference between the two groups before and after fasting and postprandial blood glucose at 2 h (P> 0.05). CONCLUSION: Insulin pump is safer and more effective than short-term insulin intravenous drip.