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目的 比较吡喹酮、丙硫咪唑单独和两药合用治疗脑实质型脑囊虫病的临床疗效。方法 90例入选病例随机分三组 ,完成治疗剂量后 3个月复诊 ,从头痛、癫痫发作等症状缓解程度及头颅MRI病灶改善情况两方面来判断及评价三组治疗方案的疗效。结果 ①联合用药组在缓解头痛、控制癫痫方面效果明显优于单独用药组(P <0 .0 5 ) ,在头颅MRI病灶改善方面有非常显著性差异 (P <0 .0 1) ;②药物不良反应三组间无明显差异。结论 对于脑实质型脑囊虫病不伴颅内压升高者 ,吡喹酮与丙硫咪唑合用疗效明显提高
Objective To compare the clinical efficacy of praziquantel and albendazole in the treatment of brain parenchymal cysticercosis with either alone or in combination of two drugs. Methods Ninety cases were randomly divided into three groups. The patients were followed up three months after the completion of treatment. The curative effects of the three treatment regimens were evaluated and evaluated from the degree of remission of headache and seizure and the improvement of cranial MRI lesions. Results ① The combined treatment group was significantly better than the single treatment group in relieving headache and controlling epilepsy (P <0.05), and there was a significant difference (P <0.01) in the improvement of cranial MRI lesions Adverse reactions no significant difference between the three groups. Conclusion For parenchymal cysticercosis without increased intracranial pressure, praziquantel and albendazole combined effect was significantly improved