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近年,化学药物治疗妇科恶性肿瘤已取得可喜进展。但化疗需长时间反复进行,药物毒性大,一些患者化疗期间发生肝功能损害而影响治疗及预后。为保证化疗顺利进行,治疗肝功能异常极其重要。我科1990年12月至1991年11月住院化疗29例,治疗中肝功能升高16例,其中10例用强力宁、猪苓多糖、干扰能治疗,效果较好,现报告如下。 资料及方法 一、10例患者治疗前概况:7例卵巢浆乳腺癌(Ⅰa期1例、Ⅰb期2例、Ⅲc期2例、Ⅳ期2例),1例宫内膜样腺棘癌Ⅰc期,1例卵巢内胚窦瘤Ⅲc期,1例妊娠性绒癌。化疗前9/10肝功能正常,但其中4例有肝病史(脂肪肝、肝硬化、弥漫性肝病各1例,澳抗阳性1例)。7/10化疗前有1次以上输血史。9/10例经行1～4次化疗后第9～20天出现肝功能异常,并经肝太乐、肌酐、肝炎灵等药物治疗2～3周无效,ALT最高达753U/ml,AST 596U/ml。仅1/10例化疗前急性肝炎。
In recent years, chemical drugs have made gratifying progress in the treatment of gynecological malignancies. However, chemotherapy should be repeated for a long time, drug toxicity, some patients during liver damage occurred during chemotherapy and treatment and prognosis. To ensure the smooth progress of chemotherapy, the treatment of abnormal liver function is extremely important. Our department from December 1990 to November 1991 29 cases of hospitalized chemotherapy, treatment of liver function in 16 cases, of which 10 cases with powerful Ning, Polyporus polysaccharide, interference can be treated, the effect is better, are as follows. Materials and Methods First, 10 patients before treatment profile: 7 cases of breast cancer ovarian tumors (Ⅰ a in 1 case, Ⅰ b in 2 cases, Ⅱ c in 2 cases, 2 cases in stage Ⅳ), 1 case of endometrial adenocarcinoma Ⅰ c Stage, 1 case of ovarian endodermal sinus tumor Ⅲc, 1 case of choriocarcinoma of pregnancy. Nine weeks before chemotherapy, liver function was normal, but 4 of them had a history of liver disease (1 case of fatty liver, cirrhosis and diffuse liver disease, 1 case of anti-O positive). 7/10 before chemotherapy more than 1 transfusion history. Nine to ten patients experienced one to four weeks after chemotherapy, liver function abnormalities were observed on days 9 to 20 and were ineffective for 2 to 3 weeks after treatment with liver-tai-le, creatinine, hepatitis and other drugs. ALT was 753U / ml and AST 596U / ml. Only 1/10 cases of acute hepatitis before chemotherapy.