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目的:检测子宫内膜样腺癌组织中基质金属蛋白酶-14(MMP-14)和组织蛋白酶-D(Cath-D)的表达特征,观察其在不同临床特征中的表达差别及相关性,以期为临床工作提供理论支持。方法:以88例子宫内膜样腺癌作为观察组,60例增生期子宫内膜组织作为对照组,采用免疫组织化学方法检测两组中MMP-14和Cath-D的表达。结果:观察组MMP-14和Cath-D表达的阳性率明显高于对照组,观察组MMP-14和Cath-D表达的阳性率与浸润深度、淋巴结转移和Ki67的表达密切相关。相关性分析显示,观察组MMP-14和Cath-D的表达呈正相关性。生存分析显示,MMP-14和Cath-D表达的阳性率与预后相关。结论:子宫内膜样腺癌组织中MMP-14和Cath-D高表达,对肿瘤的进展有促进作用,术后联合检测MMP-14和Cath-D的表达对判断子宫内膜样腺癌的预后有一定关系。
Objective: To detect the expression of matrix metalloproteinase-14 (MMP-14) and cathepsin-D (Cath-D) in endometrioid adenocarcinoma and to observe the difference and correlation between them in different clinical features, Provide theoretical support for clinical work. Methods: 88 cases of endometrial adenocarcinoma as observation group and 60 cases of proliferative endometrium as control group, immunohistochemistry was used to detect the expression of MMP-14 and Cath-D in both groups. Results: The positive rates of MMP-14 and Cath-D in the observation group were significantly higher than those in the control group. The positive rates of MMP-14 and Cath-D in the observation group were closely related to the depth of invasion, lymph node metastasis and Ki67 expression. Correlation analysis showed that the expression of MMP-14 and Cath-D in the observation group was positively correlated. Survival analysis showed that the positive rate of MMP-14 and Cath-D expression correlated with prognosis. Conclusions: The high expression of MMP-14 and Cath-D in endometrial adenocarcinoma can promote the progression of the tumor. Combined detection of the expression of MMP-14 and Cath-D in the endometrioid adenocarcinoma can be helpful for the judgment of endometrial adenocarcinoma Prognosis has a certain relationship.