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目的:分析和评价结核丸与左氧氟沙星等抗结核药物联用治疗耐多药肺结核(MDR-TB)患者的疗效。方法:复治涂阳的373例MDR-TB患者,随机分为对照组(178例)和治疗组(195例);对照组患者给予左氧氟沙星等抗结核药物(吡嗪酰胺、盐酸乙胺丁醇、对氨基水杨酸、异烟肼和利福喷丁)治疗;治疗组患者在对照组基础上加用结核丸治疗12月。结果:治疗过程中发生药物不良反应而终止治疗的13例,最终对照组实际完成175例,治疗组实际完成185例;疗程结束时,治疗组的痰菌阴转率为78.38%高于对照组为55.43%(P<0.05);治疗组患者病灶吸收有效率为78.38%和空洞闭合有效率为83.24%均高于对照组(P<0.05)。结论:结核丸与左氧氟沙星等二线抗痨药治疗耐多药肺结核患者,有利于痰菌阴转、病灶吸收和空洞闭合,并且药物不良反应的发生率较低。
OBJECTIVE: To analyze and evaluate the efficacy of TB in combination with anti-TB drugs such as levofloxacin in the treatment of MDR-TB patients. Methods: 373 MDR-TB patients were randomly divided into control group (178 cases) and treatment group (195 cases). Patients in the control group were given anti-TB drugs such as levofloxacin (pyrazinamide, ethambutol hydrochloride , P-aminosalicylic acid, isoniazid and rifapentine). Patients in the treatment group were treated with tuberculosis pills on the basis of the control group for 12 months. Results: In the course of treatment, 13 cases were terminated with adverse drug reactions. In the final control group, 175 cases were actually completed and 185 cases in the treatment group were actually completed. At the end of the treatment period, the sputum negative conversion rate in the treatment group was 78.38% higher than that in the control group Was 55.43% (P <0.05). The effective rate of the lesion in the treatment group was 78.38% and the void closure rate was 83.24% in the treatment group (P <0.05). Conclusion: Second-line anti-tuberculosis drugs such as tuberculosis pills and levofloxacin are effective in the treatment of patients with multidrug-resistant pulmonary tuberculosis because of sputum negative conversion, lesion absorption and empty closure, and the incidence of adverse drug reactions is low.