The role of human ADA2a in the regulation of p53 acetylation and stability

• 作 者: HUANG Jing ZHANG Li XIAO Lin X
• 机 构: LaboratoryofMedicalImmunology,ChineseNationalHumanGenomeCenter
• 出 处: 中国科学通报：英文版
• 发表日期: 2011年4期
• 关键词: P53基因 乙酰化 稳定 人类 调节作用 组蛋白乙酰转移酶 细胞周期阻滞 转录因子 hADA2a p53 acetylation PCAF
• 基金项目: supported by the Ministry of Science and Technology for Drug Development (2009ZX09503-004),,the National Natural Sciences Foundation of China (30901303),,Foundation for New Youth Scholars of Peking Un

The tumor suppressor protein p53 is a well-known transcription factor that functions as a critical component of the genotoxic stress response via regulating the expression of effector proteins that control cellular fate following DNA damage. The human p30